Predator: Day of the Hunter follows Theta, a survivor hunting the Yautja who slaughtered her family. In a desperate, high-stakes hunt, she traverses space, encountering multiple Predators on a frozen tundra world, while determined to kill the monster that destroyed her life.
The main storyline begins after the end of the Prometheus film and continues across different eras, such as that of Aliens, involving different characters from those seen in each film series. The comic series is divided into four mini-series related to each franchise. Each mini-series is composed of four issues. A final, double-sized issue that gives closure to the main storyline was also produced. The series ties in popular franchises such as Predator and remarks on the origins of the Aliens, and Engineers.
The events of Predator #1-4 revolve around NYC Detective Schaefer, the brother of Major Alan “Dutch” Schaefer. Detective Schaefer and his partner, Detective Rasche, discover a Predator in New York City during a drug deal gone bad. Schaefer believes the Predator and a mysterious army general have a connection to his brother, Dutch, which leads Schaefer on a hunt into Colombia. There in South America Schaefer has yet another run in with a Predator as well as a Colombian drug lord – an old NYC adversary. Successfully eluding both, Schaefer is transported back to the U.S. only to find a government plot to hand him over to the Predators. Predator #1-4 are collected together as the trade paperback: Predator: Concrete Jungle. The title should not be confused with the game of the same name. The story was also presented as a paperback mass market novel which closely follows the events depicted in the comic.