The series revolves around Gwen Stacy of Earth-65, an alternate universe version of Gwen Stacy that debuted in Edge of Spider-Verse #2 as part of the 2014–2015 Spider-Man storyline “Spider-Verse“. Spider-Gwen explores a universe where Gwen Stacy was bitten by the radioactive spider instead of Peter Parker, leading to her a career as the Spider-Woman of her world.
Gwen Stacy is back in the webs and has an all-new, all-different mystery to solve: the reappearance of The Lizard! Spider-Woman was convinced that the Lizard died in her arms along with Peter Parker. But when a similar monster goes on a reptilian rampage, she’s left with doubts not only about Peter’s life, but his death as well. And witness the debut of the Osborns of Earth-65!
EHT Comics 