Penthouse Comix began as a series of short segments in Penthouse Magazine. After 3 of these sections were printed (featuring artwork by Adam Hughes, Kevin Nowlan and Garry Leach), publisher Bob Guccione dictated that Penthouse Comix become its own stand-alone magazine, something which he envisioned competing in both US and European magazine markets. Guccione agreed to a budget that was designed to cherry pick art talent from both American comic book companies and non-US publishers and this resulted in Penthouse Comix offering a per-page rate among the highest ever paid to freelance comic book artists.
The first issue of the stand-alone Penthouse Comix was a 96-page, color, glossy magazine with cover price of $4.95 US. It appeared in spring 1994 and featured work by Adam Hughes, Garry Leach, Kevin Nowlan, Mike Harris, Arthur Suydam, Jordan Raskin, Horacio Altuna, and Milo Manara. Subsequent issues contained work by artists such as Roberto Baldazzini, Richard Corben, Tony Salmons, Bart Sears and Gray Morrow. The magazine’s early issues avoided hardcore sex in favor of “soft-core erotica” and satiric humor that poked fun at various popular genres and popular culture.



